Phenotypes associated with this allele

• Allele Symbol: Mir140⁺
• Allele Name: wild type
• Allele ID: MGI:6359839
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mir140^em1Tkob/Mir140^+	C57BL/6-Mir140^em1Tkob	MGI:6423511
cx2	Mir140^em1Asah/Mir140^+ Wwp2^Gt(HMA140)Byg/Wwp2^+	involves: 129P2/OlaHsd * C57BL/6J * DBA	MGI:6359840

Genotype
MGI:6423511

ht1

• Allelic Composition: Mir140^em1Tkob/Mir140⁺
• Genetic Background: C57BL/6-Mir140^em1Tkob

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

platyspondylia ( J:286036 )

• mice show mildly flat vertebral bodies

abnormal cartilage development ( J:286036 )

• mice show delayed cartilage maturation of the larynx, trachea, and anterior ribs

abnormal epiphyseal plate morphology ( J:286036 )

• basal skull growth plate is wider due to increased length of all layers of chondrocytes

abnormal long bone epiphyseal plate morphology ( J:286036 )

• proximal tibial growth plates show an expansion of the resting zone

delayed bone ossification ( J:286036 )

• mice show delayed secondary ossification of tubular and carpal bones

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteochondrodysplasia		DOID:2256		J:286036

Genotype
MGI:6359840

cx2

• Allelic Composition: Mir140^em1Asah/Mir140⁺; Wwp2^{Gt(HMA140)Byg}/Wwp2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA

craniofacial

decreased cranium height ( J:278573 )

skeleton

decreased cranium height ( J:278573 )