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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gykl1em#Juhu
endonuclease-mediated mutation, Junjiu Huang
MGI:6359801
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gykl1em#Juhu/Gykl1em#Juhu C57BL/6J-Gykl1em#Juhu MGI:6359847
ht2
 		Gykl1em#Juhu/Gykl1+ C57BL/6J-Gykl1em#Juhu MGI:6359848


Genotype
MGI:6359847
hm1
Allelic
Composition		 Gykl1em#Juhu/Gykl1em#Juhu
Genetic
Background		 C57BL/6J-Gykl1em#Juhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gykl1em#Juhu mutation (0 available); any Gykl1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal sperm flagellum morphology ( J:278636 )
• gap at midpiece-principal piece junction
abnormal sperm mitochondrial sheath morphology ( J:278636 )
• significantly shorter
• mitochondria concentration at end of sheath
kinked sperm flagellum ( J:278636 )
• kinked at midpiece-principal piece junction in around 96% of sperm
oligozoospermia ( J:278636 )
• fewer spermatozoa in epididymis
abnormal sperm motility ( J:278636 )
• spermatozoa swim with heads facing backwards and with twisting tails
• reduced motility, amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity

reproductive system
reproductive system phenotype ( J:278636 )
N
• normal overall testis morphology
abnormal sperm flagellum morphology ( J:278636 )
• gap at midpiece-principal piece junction
abnormal sperm mitochondrial sheath morphology ( J:278636 )
• significantly shorter
• mitochondria concentration at end of sheath
kinked sperm flagellum ( J:278636 )
• kinked at midpiece-principal piece junction in around 96% of sperm
oligozoospermia ( J:278636 )
• fewer spermatozoa in epididymis
abnormal sperm motility ( J:278636 )
• spermatozoa swim with heads facing backwards and with twisting tails
• reduced motility, amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity
male infertility ( J:278636 )
• when mated to wild-type females




Genotype
MGI:6359848
ht2
Allelic
Composition		 Gykl1em#Juhu/Gykl1+
Genetic
Background		 C57BL/6J-Gykl1em#Juhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gykl1em#Juhu mutation (0 available); any Gykl1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
kinked sperm flagellum ( J:278636 )
• kinked at midpiece-principal piece junction in around 93% of sperm
abnormal sperm motility ( J:278636 )
• reduced amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity

reproductive system
kinked sperm flagellum ( J:278636 )
• kinked at midpiece-principal piece junction in around 93% of sperm
abnormal sperm motility ( J:278636 )
• reduced amplitude of lateral head movement, beat-cross frequency, and average path, curvilinear and straight-line velocity
reduced male fertility ( J:278636 )
• 50% reduction in litter size when mated to wild-type females




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory