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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sppl2ctm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:6358787
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sppl2ctm1.1(KOMP)Vlcg/Sppl2ctm1.1(KOMP)Vlcg C57BL/6NTac-Sppl2ctm1.1(KOMP)Vlcg MGI:7385110
hm2
 		Sppl2ctm1.1(KOMP)Vlcg/Sppl2ctm1.1(KOMP)Vlcg involves: C57BL/6NCrl * C57BL/6NTac MGI:6358806
cx3
 		Frey1tm1.1(KOMP)Vlcg/Frey1tm1.1(KOMP)Vlcg
Sppl2ctm1.1(KOMP)Vlcg/Sppl2ctm1.1(KOMP)Vlcg 		C57BL/6NTac-Frey1tm1.1(KOMP)Vlcg Sppl2ctm1.1(KOMP)Vlcg MGI:7385112


Genotype
MGI:7385110
hm1
Allelic
Composition		 Sppl2ctm1.1(KOMP)Vlcg/Sppl2ctm1.1(KOMP)Vlcg
Genetic
Background		 C57BL/6NTac-Sppl2ctm1.1(KOMP)Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2ctm1.1(KOMP)Vlcg mutation (0 available); any Sppl2c mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
asthenozoospermia ( J:328498 )
• reduced motility

reproductive system
reproductive system phenotype ( J:328498 )
N
• mice exhibit normal male fertility
asthenozoospermia ( J:328498 )
• reduced motility




Genotype
MGI:6358806
hm2
Allelic
Composition		 Sppl2ctm1.1(KOMP)Vlcg/Sppl2ctm1.1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6NCrl * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2ctm1.1(KOMP)Vlcg mutation (0 available); any Sppl2c mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased elongated spermatid number ( J:272982 )
• decrease in the number of elongated spermatids per seminiferous tubule
asthenozoospermia ( J:272982 )
• decreased motility of spermatozoa recovered from the cauda epididymis
decreased testis weight ( J:272982 )
• significant decrease in normalized testis weight
decreased litter size ( J:272982 )
• decreased litter size in homozygous by homozygous crosses but not when homozygous males or females are crossed to wild-type mice

endocrine/exocrine glands
decreased testis weight ( J:272982 )
• significant decrease in normalized testis weight

cellular
decreased elongated spermatid number ( J:272982 )
• decrease in the number of elongated spermatids per seminiferous tubule
asthenozoospermia ( J:272982 )
• decreased motility of spermatozoa recovered from the cauda epididymis




Genotype
MGI:7385112
cx3
Allelic
Composition		 Frey1tm1.1(KOMP)Vlcg/Frey1tm1.1(KOMP)Vlcg
Sppl2ctm1.1(KOMP)Vlcg/Sppl2ctm1.1(KOMP)Vlcg
Genetic
Background		 C57BL/6NTac-Frey1tm1.1(KOMP)Vlcg Sppl2ctm1.1(KOMP)Vlcg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frey1tm1.1(KOMP)Vlcg mutation (1 available); any Frey1 mutation (13 available)
Sppl2ctm1.1(KOMP)Vlcg mutation (0 available); any Sppl2c mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory