Phenotypes associated with this allele

• Allele Symbol: Nos1ap^tm1Tsso
• Allele Name: targeted mutation 1, Tetsuo Sasano
• Allele ID: MGI:6358783
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nos1ap^tm1Tsso/Nos1ap^tm1Tsso	involves: C57BL/6JJcl	MGI:6358788
cx2	Nos1ap^tm1Tsso/Nos1ap^tm1Tsso Tg(Prnp-MAPT*P301S)PS19Vle/0	involves: C57BL/6 * C3H	MGI:6414672

Genotype
MGI:6358788

hm1

• Allelic Composition: Nos1ap^tm1Tsso/Nos1ap^tm1Tsso
• Genetic Background: involves: C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:268528 )

• doxycycline-treated mice die after 5 days

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

cardiovascular system

cardiovascular system phenotype ( J:268528 )

N • baseline cardiac functions are normal

decreased cardiac muscle contractility ( J:268528 )

• in doxycycline-treated mice measured by fractional shortening and calcium transient

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

ventricular tachycardia ( J:268528 )

• in doxycycline-treated mice

irregular heartbeat ( J:268528 )

• in doxycycline-treated mice

ventricular fibrillation ( J:268528 )

• in doxycycline-treated mice

ventricular premature beat ( J:268528 )

• in doxycycline-treated mice

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

prolonged QRS complex duration ( J:268528 )

• in doxycycline-treated mice just before ventricular fibrillation

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

prolonged QT interval ( J:268528 )

• in doxycycline-treated mice

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

nervous system

abnormal action potential ( J:268528 )

• action potential duration in the heart is prolonged in doxycycline-treated mice

• however, conduction velocity of the left ventricular epicardium is normal at baseline or after doxycycline treatment

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

cellular

oxidative stress ( J:268528 )

• in doxycycline-treated mice

muscle

decreased cardiac muscle contractility ( J:268528 )

• in doxycycline-treated mice measured by fractional shortening and calcium transient

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:268528 )

• doxycycline-treated mice die after 5 days

• however, pretreatment with N-acetyl-L-cysteine rescues phenotype

Genotype
MGI:6414672

cx2

• Allelic Composition: Nos1ap^tm1Tsso/Nos1ap^tm1Tsso; Tg(Prnp-MAPT*P301S)PS19Vle/0
• Genetic Background: involves: C57BL/6 * C3H

nervous system

nervous system phenotype ( J:278451 )

N • mice show reduced levels of total and phosphorylated tau and a reduction of Sarkosyl-insoluble tau indicating reduced tau pathology and ameliorated brain atrophy and neuron loss