Phenotypes associated with this allele

• Allele Symbol: Trim14^em1Rfw
• Allele Name: endonuclease-mediated mutation 1, Rong-Fu Wang
• Allele ID: MGI:6358730
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim14^em1Rfw/Trim14^em1Rfw	involves: C57BL/6J	MGI:6358732

Genotype
MGI:6358732

hm1

• Allelic Composition: Trim14^em1Rfw/Trim14^em1Rfw
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interferon-beta secretion ( J:249057 )

• mice produce lower levels of IFN-beta than wild-type controls in response to infection with HSV-1

• however, TNF-alpha production and IL-6 production are normal

increased susceptibility to Herpesvirales infection ( J:249057 )

• increased HSV-1 titer and replication in the organs after injection

• more infiltration of inflammatory cells in the lungs after intravenous injection with HSV-1

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:249057 )

• less resistant to HSV-1 infection in overall survival assays

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:249057 )

• less resistant to HSV-1 infection in overall survival assays