Analysis Tools
behavior/neurological
| N |
• adult homozygotes show normal total travel distance in the open field task, no memory deficits in the Y-maze and novelty recognition test, and normal time spent in the dark box of the light-dark box task relative to wild-type controls
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• in the elevated plus maze task, homozygotes spend significantly more time in the open arms and less time in the closed arms than controls, indicating a decreased anxiety level
• in the elevated platform task, homozygotes spend significantly more time in the outer zone and less time in the center and middle zone of the elevated platform
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growth/size/body
| N |
• adult homozygotes have normal body structure with no significant alterations in body weight relative to wild-type controls
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nervous system
| N |
• adult homozygotes have normal whole brain structure and show no obvious abnormalities in cerebral cortex and hippocampus morphology relative to wild-type controls
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