Phenotypes associated with this allele

• Allele Symbol: Orai2^tm1.2Itl
• Allele Name: targeted mutation 1.2, inGenious Targeting Laboratory
• Allele ID: MGI:6358680
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orai2^tm1.2Itl/Orai2^tm1.2Itl	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6N	MGI:6358681

Genotype
MGI:6358681

hm1

• Allelic Composition: Orai2^tm1.2Itl/Orai2^tm1.2Itl
• Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal mast cell physiology ( J:278536 )

• isolated peritoneal mast cells exhibit an increase in calcium release-activated channel currents

• intracellular calcium elevation evoked by high-affinity Fc receptors for IgE or MAS-related G protein-coupled receptor stimulation is higher for at least 10 min after agonist application in peritoneal mast cells

• calcium entry triggered by depletion of intracellular stores is increased in peritoneal mast cells at high extracellular calcium concentrations, whereas store-operated calcium entry is reduced upon re-addition of lower calcium concentration

increased mast cell degranulation ( J:278536 )

• the percentage of degranulation triggered by DNP and subsequent FCepsilonRI activation is increased in peritoneal mast cells

• degranulation evoked by compound 48-80 is increased in peritoneal mast cells

immune system

abnormal mast cell physiology ( J:278536 )

• isolated peritoneal mast cells exhibit an increase in calcium release-activated channel currents

• intracellular calcium elevation evoked by high-affinity Fc receptors for IgE or MAS-related G protein-coupled receptor stimulation is higher for at least 10 min after agonist application in peritoneal mast cells

• calcium entry triggered by depletion of intracellular stores is increased in peritoneal mast cells at high extracellular calcium concentrations, whereas store-operated calcium entry is reduced upon re-addition of lower calcium concentration

increased mast cell degranulation ( J:278536 )

• the percentage of degranulation triggered by DNP and subsequent FCepsilonRI activation is increased in peritoneal mast cells

• degranulation evoked by compound 48-80 is increased in peritoneal mast cells

mortality/aging

mortality/aging ( J:278536 )

N • mice are viable and show no obvious anatomical abnormalities

cellular

increased mast cell degranulation ( J:278536 )

• the percentage of degranulation triggered by DNP and subsequent FCepsilonRI activation is increased in peritoneal mast cells

• degranulation evoked by compound 48-80 is increased in peritoneal mast cells