Phenotypes associated with this allele

• Allele Symbol: Atp5if1^tm1Ksuj
• Allele Name: targeted mutation 1, Kyoto Sangyo University Japan
• Allele ID: MGI:6358582
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp5if1^tm1Ksuj/Atp5if1^tm1Ksuj	C57BL/6J-Atp5if1^tm1Ksuj	MGI:6358585
hm2	Atp5if1^tm1Ksuj/Atp5if1^tm1Ksuj	involves: C57BL/6J	MGI:6358588

Genotype
MGI:6358585

hm1

• Allelic Composition: Atp5if1^tm1Ksuj/Atp5if1^tm1Ksuj
• Genetic Background: C57BL/6J-Atp5if1^tm1Ksuj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:268424 )

N • mice exhibit normal breeding

growth/size/body

growth/size/body region phenotype ( J:268424 )

N • mice homozygous for a knock-out allele exhibit normal growth and response to starvation and refeeding

hematopoietic system

hematopoietic system phenotype ( J:268424 )

N • mice exhibit normal blood profiles with no signs of anemia

Genotype
MGI:6358588

hm2

• Allelic Composition: Atp5if1^tm1Ksuj/Atp5if1^tm1Ksuj
• Genetic Background: involves: C57BL/6J

cardiovascular system

abnormal cardiac muscle contractility ( J:256558 )

• mice subjected to transaortic constriction-induced pressure overload exhibit improved cardiac contraction compared to similarly treated wild-type mice

• mice subjected to isoproterenol infusion exhibit increased fractional shortening and ejection fraction without dilation nor increase in left ventricle internal dimension at both systole and diastole compared with similarly treated wild-type mice

decreased response of heart to induced stress ( J:256558 )

• mice subjected to transaortic constriction-induced pressure overload exhibit improved cardiac contraction, smaller cardiomyocyte cross-sectional area, fibrosis, and fewer apoptotic cells compared to similarly treated wild-type mice

• mice subjected to isoproterenol infusion exhibit increased fractional shortening and ejection fraction without dilation nor increase in left ventricle internal dimension at both systole and diastole compared with similarly treated wild-type mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:256558 )

• mice subjected to transaortic constriction-induced pressure overload exhibit improved cardiac contraction, smaller cardiomyocyte cross-sectional area, fibrosis, and fewer apoptotic cells compared to similarly treated wild-type mice

• mice subjected to isoproterenol infusion exhibit increased fractional shortening and ejection fraction without dilation nor increase in left ventricle internal dimension at both systole and diastole compared with similarly treated wild-type mice

muscle

abnormal cardiac muscle contractility ( J:256558 )

• mice subjected to transaortic constriction-induced pressure overload exhibit improved cardiac contraction compared to similarly treated wild-type mice

• mice subjected to isoproterenol infusion exhibit increased fractional shortening and ejection fraction without dilation nor increase in left ventricle internal dimension at both systole and diastole compared with similarly treated wild-type mice