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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Morrbidem1Flv
endonuclease-mediated mutation 1, Richard A Flavell
MGI:6358426
Summary 4 genotypes


Genotype
MGI:6358496
hm1
Allelic
Composition		 Morrbidem1Flv/Morrbidem1Flv
Genetic
Background		 C57BL/6N-Morrbidem1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
immune system phenotype ( J:236609 )
N
• mice exhibit normal eosinophil, neutrophil and monocyte progenitors
abnormal myelopoiesis ( J:236609 )
• reduced short-lived myeloid cells in mixed bone marrow chimeras
decreased eosinophil cell number ( J:236609 )
• in the blood and tissue
decreased neutrophil cell number ( J:236609 )
• in the blood and tissue
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and tissue
abnormal leukocyte physiology ( J:236609 )
• increased apoptosis of monocytes in bone marrow cultured ex vivo
abnormal eosinophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo and in vitro bone marrow-derived eosinophils
abnormal neutrophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo
increased susceptibility to bacterial infection ( J:236609 )
• mice infected with Listeria monocytogenes exhibit increased mortality, body weight loss and colony forming units in the spleen and liver compared with wild-type mice

hematopoietic system
abnormal myelopoiesis ( J:236609 )
• reduced short-lived myeloid cells in mixed bone marrow chimeras
decreased eosinophil cell number ( J:236609 )
• in the blood and tissue
decreased neutrophil cell number ( J:236609 )
• in the blood and tissue
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and tissue
abnormal leukocyte physiology ( J:236609 )
• increased apoptosis of monocytes in bone marrow cultured ex vivo
abnormal eosinophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo and in vitro bone marrow-derived eosinophils
abnormal neutrophil physiology ( J:236609 )
• increased apoptosis in bone marrow cultured ex vivo




Genotype
MGI:6358497
ht2
Allelic
Composition		 Morrbidem1Flv/Morrbid+
Genetic
Background		 C57BL/6N-Morrbidem1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Ly6C high monocyte number ( J:236609 )
• in the blood, not as severe as in homozygotes

hematopoietic system
decreased Ly6C high monocyte number ( J:236609 )
• in the blood, not as severe as in homozygotes




Genotype
MGI:6358499
cx3
Allelic
Composition		 Bcl2l11em1Flv/Bcl2l11+
Morrbid+/Morrbidem1Flv
Genetic
Background		 C57BL/6N-Bcl2l11em1Flv +/+ Morrbidem1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11em1Flv mutation (0 available); any Bcl2l11 mutation (32 available)
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:236609 )
• in the blood and spleen
decreased neutrophil cell number ( J:236609 )
• in the blood and spleen
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and spleen

hematopoietic system
decreased eosinophil cell number ( J:236609 )
• in the blood and spleen
decreased neutrophil cell number ( J:236609 )
• in the blood and spleen
decreased Ly6C high monocyte number ( J:236609 )
• in the blood and spleen




Genotype
MGI:6358501
cx4
Allelic
Composition		 Bcl2l11em1Flv/Bcl2l11+
Morrbidem1Flv/Morrbid+
Genetic
Background		 C57BL/6N-Bcl2l11em1Flv Morrbidem1Flv /+ +
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11em1Flv mutation (0 available); any Bcl2l11 mutation (32 available)
Morrbidem1Flv mutation (0 available); any Morrbid mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:236609 )
N
• short-lived myeloid cell (eosinophils, neutrophils and monocytes) numbers are normal




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory