Analysis Tools
immune system
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• following administration of 2.5% dextran sulfate sodium (DSS) in drinking water for 5 days, mutant mice showed reduced weight loss and colon length shortening relative to wild-type controls
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• 6 hours after LPS i.p. injection, serum levels of IL-12p40 were significantly lower than those in similarly treated wild-type controls
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• 6 hours after LPS i.p. injection, serum levels of IL-6 were significantly lower than those in similarly treated wild-type controls
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• bone marrow-derived macrophages (BMDMs) were unable to generate a robust LPS induction of IL-12p40
• however, BMDMs showed normal LPS induction of IL-10
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• BMDMs were unable to generate a robust LPS induction of IL-6
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• upon infection with 1 103 CFUs of S. Typhimurium via oral gavage, mutant mice showed accelerated weight loss with increased fecal CFUs 24 h after infection; mice euthanized 4 days after infection showed increased bacterial load in the cecum and higher bacterial burden and dissemination to the liver and spleen than wild-type controls
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• upon infection with 1 102 CFUs of S. Typhimurium via oral gavage, mutant mice showed accelerated bacterial dissemination and became moribund significantly faster than wild-type controls
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homeostasis/metabolism
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• 6 hours after LPS i.p. injection, serum levels of IL-12p40 were significantly lower than those in similarly treated wild-type controls
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• 6 hours after LPS i.p. injection, serum levels of IL-6 were significantly lower than those in similarly treated wild-type controls
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mortality/aging
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• upon infection with 1 102 CFUs of S. Typhimurium via oral gavage, mutant mice showed accelerated bacterial dissemination and became moribund significantly faster than wild-type controls
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digestive/alimentary system
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• following administration of 2.5% dextran sulfate sodium (DSS) in drinking water for 5 days, mutant mice showed reduced weight loss and colon length shortening relative to wild-type controls
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