Analysis Tools
taste/olfaction
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• mice show blunted responses to chorda tympani nerve recordings for exposures to the bitterant quinine, the sweeteners sucrose and SC45647, and the joint application of 2 umami tastants MSG and inosine monophosphate, but no differences to sour tastants HCl and citric acid
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• mice exhibit a reduced aversion to quinine and denatonium benzoate (bitter taste)
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• mice lack the appetitive response to moderate concentrations of NaCl
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• mice show reduced preference towards the sweetener sucrose and the non-caloric sweetener SC45647
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• mice show a blunted preference for monosodium glutamate (MSG, umami taste)
• however, mice show no change in aversion to the sour tastant hydrochloric acid
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digestive/alimentary system
| N |
• mice have an equivalent number of fungiform papillae on the anterior tongue as wild-type mice, the apical size of the circumvallate is similar to wild-type mice, taste bud and circumvallate cross-sectional morphology appear similar to controls and the number of taste buds is normal
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growth/size/body
| N |
• no differences in body weight gain are seen and no appetitive changes to regular nutritional sources are seen
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