Phenotypes associated with this allele

• Allele Symbol: Orm1^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6357675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Orm1^tm1Smoc/Orm1^tm1Smoc	involves: C57BL/6J	MGI:6460296

Genotype
MGI:6460296

hm1

• Allelic Composition: Orm1^tm1Smoc/Orm1^tm1Smoc
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired exercise endurance ( J:264446 )

• in a forced swimming test, mutant mice are only able to swim about half the length of time relative to wild-type controls

• intravenous injection of purified exogenous ORM1 restores the swimming time completely

homeostasis/metabolism

impaired exercise endurance ( J:264446 )

• in a forced swimming test, mutant mice are only able to swim about half the length of time relative to wild-type controls

• intravenous injection of purified exogenous ORM1 restores the swimming time completely

muscle

abnormal muscle electrophysiology ( J:264446 )

• in vitro, electrically evoked contractions of soleus muscle isolated from mutant mice result in a significantly lower fatigue index than that seen in wild-type muscle at 2 and 3 minutes of the stimulation

• administration of purified ORM1 restores or even increases the fatigue index suggesting that the ORM1 is an endogenous anti-fatigue protein that may directly enhance muscle endurance