Phenotypes associated with this allele

• Allele Symbol: Pnliprp1^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6356882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnliprp1^tm1Smoc/Pnliprp1^tm1Smoc	involves: 129S/SvEv * C57BL/6	MGI:6358188

Genotype
MGI:6358188

hm1

• Allelic Composition: Pnliprp1^tm1Smoc/Pnliprp1^tm1Smoc
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:278344 )

N • mice exhibit normal body weight at 4 and 10 weeks after birth

increased body fat mass ( J:278344 )

• on a normal chow diet, mice have body fat contents at 24.4%, 23.6% and 22.7% of their respective body weights, compared with 13.2%, 10.0% and 8.6% of body weights from wild-type controls at 28, 37 and 45 weeks, respectively

• after feeding high-fat diet for 10 weeks, % of fat mass increases to 27.8% relative to 17.8% in similarly fed wild-type controls

decreased lean body mass ( J:278344 )

• on a normal chow diet, mice have lean mass contents at 68.7%, 68.9% and 69.5% compared with 80.1%, 82.9% and 84.5% in wild-type mice at 28, 37 and 45 weeks, respectively

• after feeding high-fat diet for 10 weeks, % of lean mass is significantly lower than that in similarly fed wild-type controls

increased body weight ( J:278344 )

• after feeding high-fat diet for 6weeks, adult mice show significantly higher body weight than similarly fed wild-type controls

obese ( J:278344 )

• on a normal chow diet, mice develop mild mature-onset obesity with higher fat content and lower lean mass relative to wild-type controls

increased susceptibility to diet-induced obesity ( J:278344 )

• mice develop more severe obesity after feeding high-fat diet for 14 weeks

adipose tissue

increased subcutaneous adipose tissue amount ( J:278344 )

• on a normal chow diet, adult mice show increased subcutaneous fat depots relative to wild-type controls

increased abdominal adipose tissue amount ( J:278344 )

• on a normal chow diet, adult mice show increased visceral and epididymal fat depots relative to wild-type controls

increased body fat mass ( J:278344 )

• on a normal chow diet, mice have body fat contents at 24.4%, 23.6% and 22.7% of their respective body weights, compared with 13.2%, 10.0% and 8.6% of body weights from wild-type controls at 28, 37 and 45 weeks, respectively

• after feeding high-fat diet for 10 weeks, % of fat mass increases to 27.8% relative to 17.8% in similarly fed wild-type controls

increased white fat cell size ( J:278344 )

• on a normal chow diet, the size of adipocytes in white adipose tissue is larger than that in wild-type controls

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:278344 )

• mice develop more severe obesity after feeding high-fat diet for 14 weeks

impaired glucose tolerance ( J:278344 )

• on a normal chow diet, adult mice show impaired glucose tolerance with higher blood glucose at 30, 60 and 120 min after glucose administration in the GTT relative to wild-type controls

• mice show more severe glucose intolerance after feeding high-fat diet for 14 weeks

insulin resistance ( J:278344 )

• on a normal chow diet, adult mice show decreased insulin sensitivity in the ITT relative to wild-type controls

• mice show more severe insulin resistance after feeding high-fat diet for 14 weeks

abnormal enzyme/coenzyme activity ( J:278344 )

• mice show increased pancreatic lipase activity in extracted pancreatic juice relative to wild-type controls

integument

increased subcutaneous adipose tissue amount ( J:278344 )

• on a normal chow diet, adult mice show increased subcutaneous fat depots relative to wild-type controls