Analysis Tools|
Allele Symbol Allele Name Allele ID |
Zfp597tm1Hnawa targeted mutation 1, Hiroyuki Nawa MGI:6356881 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mating heterozygous mutant mice failed to produce any viable homozygous offspring; traces of abnormal embryos are absorbed to the uterus wall at E10
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• embryonic development ceases before cardiogenesis at E7.5 (egg cylinder stage)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neurodegeneration and spongiform pathology often associated with oligodendrocytes
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• spongiform changes in the dorsal striatum at P90
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• spongiform changes in the deep layers of cingulate cortex at P90
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• H&E staining revealed pigmented nuclei and vacuoles in the cingulate cortex and dorsal striatum
• only a few vacuoles in the upper cortical layers and ventral striatum
• vacuoles often associated with immunoreactivity for 2',3'-cyclic nucleotide 3'-phosphodiesterase, a cell marker for oligodendrocytes, in dorsal striatum
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• degenerative neurons with condensed nucleus and scan cytoplasm in the deep layers of cingulate cortex and dorsal striatum at P90
• no obvious signs of neurodegeneration in the cerebellum
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• spongiform changes in the deep layers of cingulate cortex and dorsal striatum at P90
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• neurodegeneration and spongiform pathology often associated with oligodendrocytes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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