Phenotypes associated with this allele

• Allele Symbol: Plekhn1^tm1.1Hkon
• Allele Name: targeted mutation 1.1, Hiroaki Konishi
• Allele ID: MGI:6356363
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plekhn1^tm1.1Hkon/Plekhn1^tm1.1Hkon	B6.Cg-Plekhn1^tm1.1Hkon	MGI:6781262

Genotype
MGI:6781262

hm1

• Allelic Composition: Plekhn1^tm1.1Hkon/Plekhn1^tm1.1Hkon
• Genetic Background: B6.Cg-Plekhn1^tm1.1Hkon

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:251603 )

♂ • although newborn and young male mice appear normal up to 12 weeks of age, males exhibit increased body weight after 20 weeks of age

♂ • in contrast, females show normal body weight from birth to 1 year of age

obese ( J:251603 )

♂ • males become obese by 36 weeks of age

♂ • although mice can survive for >2 years, body weight increase is suspended after 36 weeks of age

increased liver weight ( J:251603 )

♂ • liver weight is significantly increased in males at 36 weeks of age

adipose tissue

increased epididymal fat pad weight ( J:251603 )

♂ • epididymal fat pad weight is significantly increased in males at 36 weeks of age

abnormal brown adipose tissue physiology ( J:251603 )

♂ • protein expression of uncoupling protein 1 (UCP-1) is reduced in male BAT at 26 weeks of age

behavior/neurological

increased food intake ( J:251603 )

♂ • daily food intake is significantly increased in males fed a standard chow at 26 weeks of age

polyphagia ( J:251603 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:251603 )

♂N • no significant alterations in blood glucose levels (AUC) or plasma levels of non-esterified fatty acids (NEFAs), triglycerides, total cholesterol and monocyte chemoattractant protein-1 (MCP-1) in males at 1 year of age

♂N • normal serum levels of catecholamines and thyroid hormone (T4) in males at 26 weeks of age

increased circulating leptin level ( J:251603 )

♂ • plasma leptin level is significantly increased in males at 1 year of age

♂ • leptin mRNA level is increased in epididymal fat pads and cultured mouse embryonic fibroblasts (MEFs)

♂ • overexpression of leptin in old males is suggestive of leptin resistance that induces hyperphagia and obesity

cellular

abnormal fibroblast physiology ( J:251603 )

• generation of stress granules by arsenite treatment is inhibited in cultured MEFs

liver/biliary system

increased liver weight ( J:251603 )

♂ • liver weight is significantly increased in males at 36 weeks of age

reproductive system

reproductive system phenotype ( J:251603 )

♂N • male fertility is normal, despite relatively high endogenous gene expression level in wild-type testes