All Phenotypes Zcchc3<em1Hbsh> MGI Mouse

decreased circulating CXCL10 level ( J:271802 )

• following infection with herpes simplex virus type 1 (HSV-1), vaccinia virus (VACV) or murine cytomegalovirus (MCMV) DNA viruses, serum C-X-C motif chemokine 10 (CXCL10) levels are significantly lower than those in wild-type controls

decreased circulating interferon-beta level ( J:271802 )

• following infection with HSV-1, VACV or MCMV DNA viruses, serum IFN-beta levels are significantly lower than those in wild-type controls

decreased circulating interleukin-6 level ( J:271802 )

• following infection with HSV-1, VACV or MCMV DNA viruses, serum IL-6 levels are significantly lower than those in wild-type controls

abnormal innate immunity ( J:271802 )

• mice exhibit impaired innate immune response to DNA viruses

• cytosolic dsDNA- and DNA virus-triggered induction of downstream effector genes is inhibited in primary mouse immune cells and embryonic fibroblasts

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:271802 )

• mice are more susceptible to VACV-induced death than wild-type controls

increased susceptibility to Herpesvirales infection ( J:271802 )

• at 6 days after intranasal infection with herpes simplex virus type 1 (HSV-1), mice exhibit significantly higher HSV-1 genomic copy numbers and viral titers in the brain and greater infiltration of immune cells and tissue damage in the lungs than similarly-infected wild-type controls

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:271802 )

• mice are more susceptible to HSV-1-induced death than wild-type controls