Phenotypes associated with this allele

• Allele Symbol: Ythdf1^tm1.1Sjj
• Allele Name: targeted mutation 1.1, Sheng-Jian Ji
• Allele ID: MGI:6356298
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ythdf1^tm1.1Sjj/Ythdf1^tm1.1Sjj Tg(Atoh1-cre/Esr1*)14Fsh/0	involves: FVB/N	MGI:6719337

Genotype
MGI:6719337

cn1

• Allelic Composition: Ythdf1^tm1.1Sjj/Ythdf1^tm1.1Sjj; Tg(Atoh1-cre/Esr1*)14Fsh/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:276416 )

• embryos exhibit defects in pre-crossing commissural axon guidance, with significantly more commissural axons misprojecting into motor columns at E11.5

• pre-crossing axon guidance defects include stalling and pre-crossing turning phenotypes

• however, patterning of the spinal cord and development of dI1 commissural neurons is normal

homeostasis/metabolism

abnormal protein level ( J:276416 )

• when dorsal spinal cord (DSC) explants are dissected from pre-crossing E10.5 spinal cord and cultured in vitro, dorsal commissural axons show a dramatic reduction in Robo3.1 protein level relative to controls

• however, Robo3.1 mRNA level is not affected in the spinal cord

cellular

abnormal axon guidance ( J:276416 )

• embryos exhibit defects in pre-crossing commissural axon guidance, with significantly more commissural axons misprojecting into motor columns at E11.5

• pre-crossing axon guidance defects include stalling and pre-crossing turning phenotypes

• however, patterning of the spinal cord and development of dI1 commissural neurons is normal