About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem98em2Jkn
endonuclease-mediated mutation 2, Ian J Jackson
MGI:6355419
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem98em2Jkn/Tmem98em2Jkn C57BL/6J-Tmem98em2Jkn MGI:6358119
ht2
 		Tmem98em2Jkn/Tmem98+ C57BL/6J-Tmem98em2Jkn MGI:6358118
ht3
 		Tmem98em1Jkn/Tmem98em2Jkn C57BL/6J-Tmem98em1Jkn MGI:6358120
ht4
 		Tmem98em2Jkn/Tmem98Rwhs involves: BALB/cAnN * C3H/HeN * C57BL/6J MGI:6358121


Genotype
MGI:6358119
hm1
Allelic
Composition		 Tmem98em2Jkn/Tmem98em2Jkn
Genetic
Background		 C57BL/6J-Tmem98em2Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:277123 )
N
• pups born at expected Mendelian ratio

mortality/aging
mortality/aging ( J:277123 )
N
• viable

pigmentation
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots from age 3 months

vision/eye
vision/eye phenotype ( J:277123 )
N
• normal a-wave and b-wave amplitudes
• normal eye axial length
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots from age 3 months
abnormal retina outer nuclear layer morphology ( J:277123 )
• folds in outer nuclear layer from age 3 months




Genotype
MGI:6358118
ht2
Allelic
Composition		 Tmem98em2Jkn/Tmem98+
Genetic
Background		 C57BL/6J-Tmem98em2Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:277123 )
N
• pups born at expected Mendelian ratio

mortality/aging
mortality/aging ( J:277123 )
N
• viable

reproductive system

vision/eye
vision/eye phenotype ( J:277123 )
N
• no gross eye or retinal defects at age 5-9 months




Genotype
MGI:6358120
ht3
Allelic
Composition		 Tmem98em1Jkn/Tmem98em2Jkn
Genetic
Background		 C57BL/6J-Tmem98em1Jkn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em1Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots

vision/eye
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots
abnormal retina outer nuclear layer morphology ( J:277123 )
• folds in outer nuclear layer




Genotype
MGI:6358121
ht4
Allelic
Composition		 Tmem98em2Jkn/Tmem98Rwhs
Genetic
Background		 involves: BALB/cAnN * C3H/HeN * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem98em2Jkn mutation (0 available); any Tmem98 mutation (25 available)
Tmem98Rwhs mutation (2 available); any Tmem98 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots

vision/eye
abnormal iris pigmentation ( J:277123 )
• progressive appearance of white spots
abnormal retina outer nuclear layer morphology ( J:277123 )
• folds in outer nuclear layer




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory