Phenotypes associated with this allele

• Allele Symbol: Ecrg4^tm1.1Toko
• Allele Name: targeted mutation 1.1, Toru Kondo
• Allele ID: MGI:6355397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ecrg4^tm1.1Toko/Ecrg4^tm1.1Toko	involves: C57BL/6	MGI:6360655

Genotype
MGI:6360655

hm1

• Allelic Composition: Ecrg4^tm1.1Toko/Ecrg4^tm1.1Toko
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced spatial learning ( J:272555 )

• mice exhibit enhanced spatial learning in the Morris water maze

abnormal spatial reference memory ( J:272555 )

• mice exhibit enhanced spatial memory in the Morris water maze, with mutant mice arriving faster than wild-type mice at the platform on day 2 and improved even further on day 3

nervous system

increased neuronal stem cell self-renewal ( J:272555 )

• the number of proliferating cells in the ependymal layer and ventricular zone/subentricular zone (VZ/SVZ) is increased at 15 months of age compared to wild-type mice indicating that neural stem cell proliferation is prolonged in the brain

• adult mutant cells from 6 month old VZ/SVZ and dentate gyrus proliferative faster than wild-type cells

• neural stem cells maintain their proliferation activity in long-term culture, with proliferation of mutant cells being faster than wild-type cells and mutant cells maintaining higher proliferation activity after 60 days in culture than wild-type cells