Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baiap2l1tm1.1Arte mutation
(0 available);
any
Baiap2l1 mutation
(46 available)
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growth/size/body
N |
• homozygotes are overtly normal and show no developmental defects
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embryo
N |
• no placental defects are observed; labyrinth vascularization appears normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baiap2Gt(XG757)Byg mutation
(1 available);
any
Baiap2 mutation
(29 available)
Baiap2l1tm1.1Arte mutation
(0 available);
any
Baiap2l1 mutation
(46 available)
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mortality/aging
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• only 2.7% of double homozygotes are recovered at E18.5
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• non-resorbed embryos are detected in only 1 out of 10 litters analyzed at E18.8
• no double homozygotes are recovered at weaning
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• although double homozygotes are present at normal Mendelian ratios at E10.5, reduced numbers are detected at E14.5
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integument
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• at E14.5, almost all (14 of 15) double homozygotes show severe subcutaneous edema
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cardiovascular system
N |
• in vitro angiogenesis of E14.5 umbilical arterial explants in response to VEGF signals is normal
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• at E14.5, vessel density of double homozygotes is only ~50% of wild-type and, more significantly, 30% less than that in single Baiap2Gt(XG757)Byg homozygotes
• average lumen size of CD31+ blood vessels is ~12.4% larger than that in single Baiap2Gt(XG757)Byg homozygotes
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• at E14.5, double homozygotes exhibit early cardiac defects similar to those observed in single Baiap2Gt(XG757)Byg homozygotes
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• at E10.5, double homozygotes display heart tube malformations
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• at E14.5, double homozygotes show incomplete IVS closure
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• at E14.5, double homozygotes show malformation of the mesenchymal membranous part of the septa
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• at E14.5, the heart right ventricles are misshapen
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• at E10.5, double homozygotes exhibit pericardial edema with similar ratios as single Baiap2Gt(XG757)Byg homozygotes
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embryo
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• at E14.5, vessel density of double homozygotes is only ~50% of wild-type and, more significantly, 30% less than that in single Baiap2Gt(XG757)Byg homozygotes
• average lumen size of CD31+ blood vessels is ~12.4% larger than that in single Baiap2Gt(XG757)Byg homozygotes
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• at E14.5, patches of trophoblast giant cells are observed in the spongiotrophoblast layer
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• at E14.5, placentas exhibit a much thinner and significantly more disorganized Tpbpa+ spongiotrophoblast layer than that in single Baiap2Gt(XG757)Byg homozygotes
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homeostasis/metabolism
limbs/digits/tail
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• at E14.5, almost all (13 of 15) double homozygotes show forepaw oligodactyly; loss of posterior digits in the right forepaw is observed
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