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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stx3Gt(EUCE320f12)1.2Hmgu
gene trap EUCE320f12, derivative 1.2, Helmholtz Zentrum Muenchen GmbH
MGI:6355364
Summary 2 genotypes


Genotype
MGI:7469800
hm1
Allelic
Composition		 Stx3Gt(EUCE320f12)1.2Hmgu/Stx3Gt(EUCE320f12)1.2Hmgu
Genetic
Background		 B6.129P2(Cg)-Stx3Gt(EUCE320f12)1.2Hmgu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx3Gt(EUCE320f12)1.2Hmgu mutation (0 available); any Stx3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:275367 )
• heterozygous intercrosses fail to produce homozygotes; reported as embryonic lethal but stage of lethality is not specified




Genotype
MGI:7469801
ht2
Allelic
Composition		 Stx3Gt(EUCE320f12)1.2Hmgu/Stx3+
Genetic
Background		 B6.129P2(Cg)-Stx3Gt(EUCE320f12)1.2Hmgu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stx3Gt(EUCE320f12)1.2Hmgu mutation (0 available); any Stx3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:275367 )
N
• in a model of passive systemic anaphylaxis, mice sensitized i.p. with anti-DNP IgE and challenged i.p. with DNP-HAS exhibit a normal hypothermic response at 50 min post-challenge
abnormal mast cell degranulation ( J:275367 )
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis

hematopoietic system
abnormal mast cell degranulation ( J:275367 )
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis

mortality/aging
mortality/aging ( J:275367 )
N
• mice are viable, grossly normal, and exhibit a normal life span when raised in a specific pathogen-free facility

cellular
abnormal mast cell degranulation ( J:275367 )
• plasma membrane capacitance (Cm) recordings of single peritoneal mast cells (MCs) after stimulation by intracellular dialysis of GTPgammaS and Ca2+ show that MCs achieve the same total increase in plasma membrane area (deltaCm) at a significantly lower rate than wild-type MCs; however, time between cell access and beginning of the exocytic burst is normal
• after stimulation with PMA/ionomycin, peritoneal MCs show a significant reduction in intracellular multigranular compartments, indicating a partial defect in compound exocytosis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory