Phenotypes associated with this allele

• Allele Symbol: Tctn3^tm1.2Blnw
• Allele Name: targeted mutation 1.2, Baolin Wang
• Allele ID: MGI:6343517
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tctn3^tm1.2Blnw/Tctn3^tm1.2Blnw	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SW	MGI:6360560

Genotype
MGI:6360560

hm1

• Allelic Composition: Tctn3^tm1.2Blnw/Tctn3^tm1.2Blnw
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SW

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:249241 )

• homozygotes die between E14.5 and E16.5

neonatal lethality, complete penetrance ( J:249241 )

• occasionally pups are born but die within one day (P0)

embryo

decreased embryonic neuroepithelium primary cilium number ( J:249241 )

• cilia number is reduced in the neural epithelia in the neural tube

absent floor plate ( J:249241 )

• mutants lack the floor plate in the neural tube

cardiovascular system

abnormal direction of heart looping ( J:249241 )

• 8 of 28 mutants develop with hearts that turn in a rightward rather than leftward orientation, indicating randomized heart looping

homeostasis/metabolism

edema ( J:249241 )

• edema in the back of the upper body

limbs/digits/tail

polydactyly ( J:249241 )

nervous system

decreased embryonic neuroepithelium primary cilium number ( J:249241 )

• cilia number is reduced in the neural epithelia in the neural tube

absent floor plate ( J:249241 )

• mutants lack the floor plate in the neural tube

holoprosencephaly ( J:249241 )

• homozygotes exhibit holoprosencephaly as evidenced by incomplete separation of prosencephalon

cellular

abnormal cilium morphology ( J:249241 )

• cilia number is reduced in all embryo tissues examined, including neural epithelia in the neural tube and mesencephalic vesicle, perineural tube area, and notochord

• cilia number is reduced in mouse embryonic fibroblasts

decreased embryonic neuroepithelium primary cilium number ( J:249241 )

• cilia number is reduced in the neural epithelia in the neural tube