Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm13(tetO-Nup88)Jvd}
• Allele Name: targeted mutation 13, Jan MA van Deursen
• Allele ID: MGI:6343327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Col1a1^tm13(tetO-Nup88)Jvd/Col1a1^+	involves: 129S4/SvJae * C57BL/6	MGI:6377633

Genotype
MGI:6377633

ht1

• Allelic Composition: Col1a1^{tm13(tetO-Nup88)Jvd}/Col1a1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

aneuploidy ( J:231166 )

• dox-treated MEFs exhibit higher aneuploidy rates

• splenocytes from 5 month old dox-treated mice show about 4-fold higher rates of aneuploidy than control splenocytes

• lung tissues from 5 month old dox-treated mice are more aneuploid than control lung tissues

abnormal cell cycle checkpoint function ( J:231166 )

• dox-treated MEFs exhibit mitotic checkpoint defects

abnormal mitosis ( J:231166 )

• dox-treated MEFs have higher rates of chromatin bridges and lagging chromosomes, indicating chromosomal segregation defects

• dox-treated MEFs exhibit increased incomplete centrosome separation

• MEFs treated with the PLK inhibitor BI2536 show restoration of normal centrosome separation

abnormal mitotic spindle morphology ( J:231166 )

• dox-treated MEFs exhibit more frequent spindle geometry defects showing mitotic spindle asymmetry

chromosomal instability ( J:231166 )

neoplasm

increased tumor incidence ( J:231166 )

• mice administered doxycycline (dox) beginning at weaning are prone to spontaneous tumors, particularly lung tumors, by 14 months of age, with 56% of mice having at least one neoplastic lesion compared to 21% of controls

increased lung tumor incidence ( J:231166 )

• in dox-treated mice

respiratory system

increased lung tumor incidence ( J:231166 )

• in dox-treated mice