All Phenotypes Fbxw11<tm2Nakay> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fbxw11^tm2Nakay
targeted mutation 2, Keiko Nakayama
MGI:6343252

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay	MGI:6781888

Allelic Composition	Fbxw11^tm2Nakay/Fbxw11^tm1Nakay
Genetic Background	B6.Cg-Fbxw11^tm2Nakay Fbxw11^tm1Nakay

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw11^tm1Nakay mutation (0 available); any Fbxw11 mutation (71 available)
Fbxw11^tm2Nakay mutation (0 available); any Fbxw11 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased fibroblast proliferation ( J:228222 )

• after Cre retrovirus infection (to delete the floxed allele), primary mouse embryonic fibroblasts (MEFs) derived from E13.5 embryos show significantly decreased cell proliferation relative to wild-type MEFs

• no differences in oncogene-induced cellular replicative senescence or apoptosis are observed

• defect in MEF proliferation can be rescued by beta-TrCP2 overexpression, but not by beta-TrCP1 overexpression

• arrest in MEF proliferation is induced by stabilization and abnormal accumulation of Cdkn2a (also known as p19^ARF)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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