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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dp(11Arf2-Kansl1)9Yah
duplication, Chr 11, Yann Herault 9
MGI:6342922
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dp(11Arf2-Kansl1)9Yah/Del(11Arf2-Kansl1)8Yah involves: 129S1/Sv * C57BL/6NTac MGI:8166430
ot2
Dp(11Arf2-Kansl1)9Yah/0 involves: 129S1/Sv * C57BL/6NTac MGI:8166400


Genotype
MGI:8166430
cx1
Allelic
Composition
Dp(11Arf2-Kansl1)9Yah/Del(11Arf2-Kansl1)8Yah
Genetic
Background
involves: 129S1/Sv * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(11Arf2-Kansl1)8Yah mutation (1 available); any Del(11Arf2-Kansl1)8Yah mutation (1 available)
Dp(11Arf2-Kansl1)9Yah mutation (1 available); any Dp(11Arf2-Kansl1)9Yah mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 20 weeks of age
• at 20 weeks of age

adipose tissue
• mice exhibit lower adiposity levels at 20 weeks of age




Genotype
MGI:8166400
ot2
Allelic
Composition
Dp(11Arf2-Kansl1)9Yah/0
Genetic
Background
involves: 129S1/Sv * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(11Arf2-Kansl1)9Yah mutation (1 available); any Dp(11Arf2-Kansl1)9Yah mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• mice exhibit lower adiposity levels at 20 weeks of age

behavior/neurological
N
• mice show no differences in the elevated plus maze, in motor coordination and learning on the rotarod, in the novel object recognition test or in muscular strength on the grip test
• in the fear conditioning test, mice exhibit a higher level of freezing with significant differences in the last 2 minutes of test in the context session
• during the presentation of the conditioning cue of the fear conditioning test, mice show higher levels of freezing during the second 2-minute long cue
• mice show higher levels of freezing in a fear conditioning/extinction protocol with reinforced conditioned stimuli suggesting that fear trace persists

growth/size/body
• at 20 weeks of age
• at 20 weeks of age

nervous system
• reduction in brain volume, with reductions in hippocampus, amygdala, nucleus accumbens, cingulate complex, entorhinal cortex, frontal region, and perirhinal cortex volume

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chromosome 17q21.31 duplication syndrome DOID:0060434 OMIM:613533
J:244312





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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory