Analysis Tools|
Allele Symbol Allele Name Allele ID |
Dp(11Arf2-Kansl1)9Yah duplication, Chr 11, Yann Herault 9 MGI:6342922 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 20 weeks of age
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• at 20 weeks of age
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• mice exhibit lower adiposity levels at 20 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit lower adiposity levels at 20 weeks of age
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| N |
• mice show no differences in the elevated plus maze, in motor coordination and learning on the rotarod, in the novel object recognition test or in muscular strength on the grip test
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• in the fear conditioning test, mice exhibit a higher level of freezing with significant differences in the last 2 minutes of test in the context session
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• during the presentation of the conditioning cue of the fear conditioning test, mice show higher levels of freezing during the second 2-minute long cue
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• mice show higher levels of freezing in a fear conditioning/extinction protocol with reinforced conditioned stimuli suggesting that fear trace persists
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• at 20 weeks of age
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• at 20 weeks of age
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• reduction in brain volume, with reductions in hippocampus, amygdala, nucleus accumbens, cingulate complex, entorhinal cortex, frontal region, and perirhinal cortex volume
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| chromosome 17q21.31 duplication syndrome | DOID:0060434 |
OMIM:613533 |
J:244312 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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