Phenotypes associated with this allele

• Allele Symbol: Stpg4^em1Ogu
• Allele Name: endonuclease-mediated mutation 1, Atsuo Ogura
• Allele ID: MGI:6342882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stpg4^em1Ogu/Stpg4^em1Ogu	involves: C57BL/6 * DBA/2	MGI:7439320

Genotype
MGI:7439320

hm1

• Allelic Composition: Stpg4^em1Ogu/Stpg4^em1Ogu
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA methylation ( J:254851 )

• conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is impaired in maternal zygotes: the 5mC level remains high while the 5hmC level remains low in the male pronucleus

• immunofluorescence analysis of Tet3 (a 5mC-oxidizing enzyme responsible for active DNA demethylation) shows a significantly reduced Tet3 signal in maternal zygotes

growth/size/body

growth/size/body region phenotype ( J:254851 )

N • homozygotes are normal in terms of gross appearance and growth rate

reproductive system

reproductive system phenotype ( J:254851 )

N • natural mating of homozygous pairs of mice results in normal litter sizes at birth