Phenotypes associated with this allele

• Allele Symbol: Fbxw18^{em1(IMPC)Ccpcz}
• Allele Name: endonuclease-mediated mutation 1, Institute of Molecular Genetics
• Allele ID: MGI:6341894
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw18^em1(IMPC)Ccpcz/Fbxw18^em1(IMPC)Ccpcz	C57BL/6N-Fbxw18^em1(IMPC)Ccpcz/Ccpcz	MGI:6731325
ht2	Fbxw18^em1(IMPC)Ccpcz/Fbxw18^+	C57BL/6N-Fbxw18^em1(IMPC)Ccpcz/Ccpcz	MGI:6731324

Genotype
MGI:6731325

hm1

• Allelic Composition: Fbxw18^{em1(IMPC)Ccpcz}/Fbxw18^{em1(IMPC)Ccpcz}
• Genetic Background: C57BL/6N-Fbxw18^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Fbxw18

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal tooth morphology ( J:211773 )

♂

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

abnormal tooth morphology ( J:211773 )

♂

IMPC - CCP-IMG

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - CCP-IMG

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - CCP-IMG

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

skeleton

abnormal tooth morphology ( J:211773 )

♂

IMPC - CCP-IMG

Genotype
MGI:6731324

ht2

• Allelic Composition: Fbxw18^{em1(IMPC)Ccpcz}/Fbxw18⁺
• Genetic Background: C57BL/6N-Fbxw18^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Fbxw18

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

craniofacial

abnormal tooth morphology ( J:211773 )

♀

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - CCP-IMG

small seminal vesicle ( J:211773 )

♂

IMPC - CCP-IMG

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

abnormal tooth morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

small spleen ( J:211773 )

♂

IMPC - CCP-IMG

homeostasis/metabolism

increased circulating sodium level ( J:211773 )

IMPC - CCP-IMG

increased circulating chloride level ( J:211773 )

♀

IMPC - CCP-IMG

immune system

abnormal thymus morphology ( J:211773 )

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

small spleen ( J:211773 )

♂

IMPC - CCP-IMG

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - CCP-IMG

nervous system

abnormal brain morphology ( J:211773 )

♂

IMPC - CCP-IMG

hydrocephaly ( J:211773 )

♂

IMPC - CCP-IMG

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - CCP-IMG

small seminal vesicle ( J:211773 )

♂

IMPC - CCP-IMG

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

small testis ( J:211773 )

♂

IMPC - CCP-IMG

skeleton

abnormal tooth morphology ( J:211773 )

♀

IMPC - CCP-IMG