Phenotypes associated with this allele

• Allele Symbol: Slx1b^em1(IMPC)Ics
• Allele Name: endonuclease-mediated mutation 1, Mouse Clinical Institute
• Allele ID: MGI:6336095
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Slx1b^em1(IMPC)Ics/Slx1b^+	C57BL/6N-Slx1b^em1(IMPC)Ics/Ics	MGI:6408670

Genotype
MGI:6408670

ht1

• Allelic Composition: Slx1b^em1(IMPC)Ics/Slx1b⁺
• Genetic Background: C57BL/6N-Slx1b^em1(IMPC)Ics/Ics

Data Sources

IMPC Data for Slx1b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - ICS

nervous system

increased brain size ( J:343325 )

• in adult males, the total brain area is enlarged by 7% relative to wild-type males

• in adult females, the total brain area is enlarged by 6% relative to wild-type females

increased corpus callosum size ( J:343325 )

• in adult males, the area of the genu of the corpus callosum is enlarged by 11%, while the soma of the corpus callosum is enlarged by 10% and the height of the corpus callosum is increased by 14% relative to wild-type males

• in adult females, the soma of the corpus callosum is enlarged by 10% and the height of the corpus callosum is increased by 9% relative to wild-type females

abnormal hippocampal commissure morphology ( J:343325 )

♂ • in adult males, the area of the dorsal hippocampal commissure is enlarged by 20% relative to wild-type males

increased dentate gyrus size ( J:343325 )

♂ • in adult males, the length of the dentate gyrus is increased by 10% relative to wild-type males