Analysis Tools
homeostasis/metabolism
| N |
• serum creatinine, blood urea nitrogen and urinary albumin-to-creatinine ratio measurements are not altered
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Allele Symbol Allele Name Allele ID |
Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz transgene insertion, Katalin Susztak MGI:6331299 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• serum creatinine, blood urea nitrogen and urinary albumin-to-creatinine ratio measurements are not altered
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• doxycycline-treated mice exhibit albuminuria, as indicated by higher urinary-albumin-to-creatinine ratio level
• mice treated with doxycycline for 14 days and then taken off it for 7 or 17 days, show halted albuminuria development
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• doxycycline-treated mice exhibit albuminuria, as indicated by higher urinary-albumin-to-creatinine ratio level
• mice treated with doxycycline for 14 days and then taken off it for 7 or 17 days, show halted albuminuria development
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• marker analysis indicated severe podocyte dedifferentiation in doxycycline-treated mice
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• doxycycline-treated mice exhibit increased foot-process effacement
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• podocyte number is reduced in doxycycline-treated mice
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• increase in number of multivesicular bodies, amphisomes, and autophagosomes in podocytes of doxycycline-treated mice
• the ratio of autophagic vacuoles to autolysosomes is increased in podocytes of doxycycline-treated mice, indicating an increase in autophagic vacuole content
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• doxycycline-treated mice show an increase in global and segmental glomerulosclerosis
• by 3 weeks after doxycycline induction, mice develop severe global and segmental sclerosis
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• podocytes from doxycycline-treated mice show increased inflammatory cell death (pyroptosis)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| kidney disease | DOID:557 | J:251848 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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