Phenotypes associated with this allele

• Allele Symbol: Kctd13^em2(IMPC)Ics
• Allele Name: endonuclease-mediated mutation 2, Mouse Clinical Institute
• Allele ID: MGI:6324167
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kctd13^em2(IMPC)Ics/Kctd13^em2(IMPC)Ics	C57BL/6N-Kctd13^em2(IMPC)Ics/Ics	MGI:6408464
ht2	Kctd13^em2(IMPC)Ics/Kctd13^+	C57BL/6N-Kctd13^em2(IMPC)Ics/Ics	MGI:8209509

Genotype
MGI:6408464

hm1

• Allelic Composition: Kctd13^em2(IMPC)Ics/Kctd13^em2(IMPC)Ics
• Genetic Background: C57BL/6N-Kctd13^em2(IMPC)Ics/Ics

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased cingulate cortex size ( J:343325 )

♀ • in adult females, the area of the cingulate cortex is significantly reduced relative to wild-type females

abnormal hippocampus pyramidal cell layer ( J:343325 )

♂ • in adult males, the total internal length of the pyramidal layer is significantly reduced relative to wild-type males

small hippocampus ( J:343325 )

♂ • in adult males, the area of the hippocampus is reduced by 10% relative to wild-type males

decreased secondary somatosensory cortex size ( J:343325 )

♀ • in adult females, the height of the secondary somatosensory cortex is reduced relative to wild-type females

Genotype
MGI:8209509

ht2

• Allelic Composition: Kctd13^em2(IMPC)Ics/Kctd13⁺
• Genetic Background: C57BL/6N-Kctd13^em2(IMPC)Ics/Ics

nervous system

nervous system phenotype ( J:343325 )

N • adult male and female mice show no significant differences in any of the brain neuroanatomical parameters measured on two coronal sections (at bregma +0.98 mm and bregma -1.34 mm) in five major categories (brain size, commissure, ventricle, cortex, and subcortex) relative wild-type controls