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Allele Symbol Allele Name Allele ID |
Secisbp2tm1.2Amdu targeted mutation 1.2, Alexandra M Dumitrescu MGI:6323602 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with tamoxifen starting at P25 show severe failure to thrive and lethality by 3 weeks after tamoxifen injection in most mice
• mice treated with tamoxifen for 4 days starting at P28 to P35 survive to at least 10 months after tamoxifen injection
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• mice exhibit 16% decreased body weight 2 weeks after starting tamoxifen injection, and 24% and 26% decreased weight in males and females, respectively, at 4 weeks postinjection
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• the product of serum TSH and T4 levels, known as T4 resistance index, is increased 5.3-fold in males and 12.4-fold in females after tamoxifen treatment, indicating pituitary resistance to circulating TH levels
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• males exhibit a 3.5-fold increase and females a 9.8-fold increase in TSH 4 weeks after starting tamoxifen injection
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• males exhibit a 2.3-fold increase and females a 1.4-fold increase in rT3 levels 4 weeks after starting tamoxifen injection
• however, T3 levels are similar to controls
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• males exhibit a 1.5-fold increase and females a 1.3-fold increase in T4 levels 4 weeks after starting tamoxifen injection
• liver T4 content is increased by 1.4-fold in both tamoxifen treated males and females
• however, liver T3 content is normal
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• tamoxifen treated mice exhibit a 0.7-fold decrease in T3/T4 ratio, indicating decreased efficiency in generating circulating T3
• cerebral T3 content is decreased 29% and 35% in males and females, respectively, after tamoxifen treatment
• the ratio of liver to serum T3 concentrations is decreased and ratios of T3/T4 content is decreased by 0.6- and 0.7-fold in tamoxifen-treated males and females, respectively, suggesting a decrease of local T3 generation
• however, serum T3 levels and liver T3 content are normal in tamoxifen-treated mice
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• type 1 deiodinase (D1) enzymatic activity is decreased by 69% and 51% in males and females, respectively
• type 2 deiodinase (D2) enzymatic activity is decreased by 47% and 52% in males and females, respectively, after tamoxifen treatment
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• the product of serum TSH and T4 levels, known as T4 resistance index, is increased 5.3-fold in males and 12.4-fold in females after tamoxifen treatment, indicating pituitary resistance to circulating TH levels
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• mice treated with tamoxifen starting at P28 are infertile in matings with control mice for more than 6 months
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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