All Phenotypes Ptprc<m12Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptprc^m12Btlr
mutation 12, Bruce Beutler
MGI:6305858

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^m12Btlr/Ptprc^m12Btlr	C57BL/6J-Ptprc^m12Btlr	MGI:6305860

Allelic Composition	Ptprc^m12Btlr/Ptprc^m12Btlr
Genetic Background	C57BL/6J-Ptprc^m12Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprc^m12Btlr mutation (0 available); any Ptprc mutation (188 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B-1 B cell number ( J:274972 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274972 )

• reduced frequencies of B cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274972 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274972 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system

increased B-1 B cell number ( J:274972 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274972 )

• reduced frequencies of B cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:274972 )

• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

decreased T cell number ( J:274972 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD4+ T cells in the peripheral blood

decreased effector memory CD4-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:274972 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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