Phenotypes associated with this allele

• Allele Symbol: Nfkb2^m3Btlr
• Allele Name: mutation 3, Bruce Beutler
• Allele ID: MGI:6305796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkb2^m3Btlr/Nfkb2^m3Btlr	C57BL/6J-Nfkb2^m3Btlr	MGI:6305798

Genotype
MGI:6305798

hm1

• Allelic Composition: Nfkb2^m3Btlr/Nfkb2^m3Btlr
• Genetic Background: C57BL/6J-Nfkb2^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:274960 )

• reduced expression of B220 on peripheral blood B cells

abnormal T cell differentiation ( J:274960 )

• reduced CD44 expression on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274960 )

• reduced CD44 expression on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274960 )

• reduced CD44 expression on peripheral blood CD8+ T cells

increased B-1 B cell number ( J:274960 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274960 )

• reduced frequencies of B cells in the peripheral blood

• reduced peripheral blood B to T cell ratios

decreased NK cell number ( J:274960 )

• reduced frequencies of NK cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274960 )

• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced peripheral blood CD4 to CD8 T cell ratios

decreased effector memory CD8-positive, alpha-beta T cell number ( J:274960 )

• reduced frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, naive alpha-beta T cell number ( J:274960 )

• increased frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274960 )

• increased frequencies of T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:274960 )

• increased frequencies of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274960 )

• increased frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system

abnormal B cell differentiation ( J:274960 )

• reduced expression of B220 on peripheral blood B cells

abnormal T cell differentiation ( J:274960 )

• reduced CD44 expression on peripheral blood T cells

abnormal CD4-positive T cell differentiation ( J:274960 )

• reduced CD44 expression on peripheral blood CD4+ T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:274960 )

• reduced CD44 expression on peripheral blood CD8+ T cells

increased B-1 B cell number ( J:274960 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:274960 )

• reduced frequencies of B cells in the peripheral blood

• reduced peripheral blood B to T cell ratios

decreased NK cell number ( J:274960 )

• reduced frequencies of NK cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:274960 )

• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

• reduced peripheral blood CD4 to CD8 T cell ratios

decreased effector memory CD8-positive, alpha-beta T cell number ( J:274960 )

• reduced frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, naive alpha-beta T cell number ( J:274960 )

• increased frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood

increased T cell number ( J:274960 )

• increased frequencies of T cells in the peripheral blood

increased CD4-positive, alpha-beta T cell number ( J:274960 )

• increased frequencies of CD4+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:274960 )

• increased frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood