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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd3em2Btlr
mutation 2, Bruce Beutler
MGI:6305303
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd3em2Btlr/Cd3em2Btlr C57BL/6J-Cd3em2Btlr MGI:6305305


Genotype
MGI:6305305
hm1
Allelic
Composition		 Cd3em2Btlr/Cd3em2Btlr
Genetic
Background		 C57BL/6J-Cd3em2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3em2Btlr mutation (0 available); any Cd3e mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:274934 )
• expression of CD44 was increased on peripheral blood T cells
• reduced peripheral blood CD4+ to CD8+ T cell ratios
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274934 )
• expression of CD44 was increased on peripheral blood CD8+ T cells
decreased CD4-positive, alpha-beta T cell number ( J:274934 )
• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274934 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:274934 )
• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:274934 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

hematopoietic system
abnormal T cell differentiation ( J:274934 )
• expression of CD44 was increased on peripheral blood T cells
• reduced peripheral blood CD4+ to CD8+ T cell ratios
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274934 )
• expression of CD44 was increased on peripheral blood CD8+ T cells
decreased CD4-positive, alpha-beta T cell number ( J:274934 )
• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274934 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
increased CD8-positive, alpha-beta T cell number ( J:274934 )
• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:274934 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory