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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PtprcM11Btlr
mutation 11, Bruce Beutler
MGI:6305154
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PtprcM11Btlr/PtprcM11Btlr C57BL/6J-PtprcM11Btlr MGI:6305156


Genotype
MGI:6305156
hm1
Allelic
Composition		 PtprcM11Btlr/PtprcM11Btlr
Genetic
Background		 C57BL/6J-PtprcM11Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PtprcM11Btlr mutation (0 available); any Ptprc mutation (212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:274863 )
• reduced B220 expression on peripheral blood B cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274863 )
• increased expression of CD44 on peripheral blood CD8 T cells
increased B-1 B cell number ( J:274863 )
• increased frequencies of B1 cells in the peripheral blood

hematopoietic system
abnormal B cell differentiation ( J:274863 )
• reduced B220 expression on peripheral blood B cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274863 )
• increased expression of CD44 on peripheral blood CD8 T cells
increased B-1 B cell number ( J:274863 )
• increased frequencies of B1 cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory