About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc5m1Btlr
mutation 1, Bruce Beutler
MGI:6304305
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Xrcc5m1Btlr/Xrcc5m1Btlr C57BL/6J-Xrcc5m1Btlr MGI:6304307


Genotype
MGI:6304307
hm1
Allelic
Composition		 Xrcc5m1Btlr/Xrcc5m1Btlr
Genetic
Background		 C57BL/6J-Xrcc5m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5m1Btlr mutation (0 available); any Xrcc5 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:274736 )
• increased B220 on peripheral blood B cells
abnormal T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood CD8+ T cells
increased neutrophil cell number ( J:274736 )
• increased frequencies of neutrophils in the peripheral blood
increased dendritic cell number ( J:274736 )
• increased frequencies of CD11c+ DCs in the peripheral blood
decreased B-2 B cell number ( J:274736 )
• reduced frequencies of B2 cells in the peripheral blood
increased B-1a cell number ( J:274736 )
• increased frequencies of B1a cells in the peripheral blood
increased B-1b cell number ( J:274736 )
• increased frequencies of B1b cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274736 )
• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood
decreased T cell number ( J:274736 )
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD4+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system
abnormal B cell differentiation ( J:274736 )
• increased B220 on peripheral blood B cells
abnormal T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274736 )
• increased expression of CD44 on peripheral blood CD8+ T cells
increased neutrophil cell number ( J:274736 )
• increased frequencies of neutrophils in the peripheral blood
increased dendritic cell number ( J:274736 )
• increased frequencies of CD11c+ DCs in the peripheral blood
decreased B-2 B cell number ( J:274736 )
• reduced frequencies of B2 cells in the peripheral blood
increased B-1a cell number ( J:274736 )
• increased frequencies of B1a cells in the peripheral blood
increased B-1b cell number ( J:274736 )
• increased frequencies of B1b cells in the peripheral blood
increased CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274736 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274736 )
• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood
decreased T cell number ( J:274736 )
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD4+ T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274736 )
• reduced frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory