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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themism5Btlr
mutation 5, Bruce Beutler
MGI:6304287
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Themism5Btlr/Themism5Btlr C57BL/6J-Themism5Btlr MGI:6304289


Genotype
MGI:6304289
hm1
Allelic
Composition		 Themism5Btlr/Themism5Btlr
Genetic
Background		 C57BL/6J-Themism5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themism5Btlr mutation (0 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:274716 )
• expression of CD44 was increased on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:274716 )
• expression of CD44 was increased on peripheral blood CD4+ T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274716 )
• expression of CD44 was increased on peripheral blood CD8+ T cells
increased central memory CD4-positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased CD8-positive, alpha-beta memory T cell number ( J:274716 )
• increased frequencies of CD44+ CD8 T cells in the peripheral blood
• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274716 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
increased NK T cell number ( J:274716 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased alpha-beta T cell number ( J:274716 )
• increased peripheral blood B to T cell ratios
• reduced peripheral blood CD4 to CD8 T cell ratios
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274716 )
• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood
• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274716 )
• reduced frequencies of CD8+ T cells in the peripheral blood

immune system
abnormal T cell differentiation ( J:274716 )
• expression of CD44 was increased on peripheral blood T cells
abnormal CD4-positive T cell differentiation ( J:274716 )
• expression of CD44 was increased on peripheral blood CD4+ T cells
abnormal CD8-positive, alpha-beta T cell differentiation ( J:274716 )
• expression of CD44 was increased on peripheral blood CD8+ T cells
increased central memory CD4-positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood
increased effector memory CD4-positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood
increased CD8-positive, alpha-beta memory T cell number ( J:274716 )
• increased frequencies of CD44+ CD8 T cells in the peripheral blood
• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood
increased central memory CD8 positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood
increased effector memory CD8-positive, alpha-beta T cell number ( J:274716 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased CD8-positive, naive alpha-beta T cell number ( J:274716 )
• reduced frequencies of nave CD8 T cells in CD8 T cells in the peripheral blood
increased NK T cell number ( J:274716 )
• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood
decreased alpha-beta T cell number ( J:274716 )
• increased peripheral blood B to T cell ratios
• reduced peripheral blood CD4 to CD8 T cell ratios
• reduced frequencies of T cells in the peripheral blood
decreased CD4-positive, alpha-beta T cell number ( J:274716 )
• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood
• reduced frequencies of naive CD4 T cells in CD4 T cells in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:274716 )
• reduced frequencies of CD8+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory