Phenotypes associated with this allele

• Allele Symbol: Eif3e^tm1Fshb
• Allele Name: targeted mutation 1, Futoshi Shibasaki
• Allele ID: MGI:6295473
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif3e^tm1Fshb/Eif3e^tm1Fshb	C57BL/6N-Eif3e^tm1Fshb	MGI:6295476
ht2	Eif3e^tm1Fshb/Eif3e^+	C57BL/6N-Eif3e^tm1Fshb	MGI:6295477

Genotype
MGI:6295476

hm1

• Allelic Composition: Eif3e^tm1Fshb/Eif3e^tm1Fshb
• Genetic Background: C57BL/6N-Eif3e^tm1Fshb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:265010 )

• fewer than expected mice are present at E10.5

prenatal lethality, complete penetrance ( J:265010 )

• no mice are produced from mating heterozygotes

growth/size/body

decreased embryo size ( J:265010 )

• with hypoplasia

embryo

decreased embryo size ( J:265010 )

• with hypoplasia

abnormal extraembryonic tissue morphology ( J:265010 )

• small fetal membranes at E12.5

Genotype
MGI:6295477

ht2

• Allelic Composition: Eif3e^tm1Fshb/Eif3e⁺
• Genetic Background: C57BL/6N-Eif3e^tm1Fshb

cellular

cellular phenotype ( J:265010 )

N • mouse embryonic fibroblasts exhibit normal cell survival

decreased fibroblast proliferation ( J:265010 )

• in mouse embryonic fibroblasts

abnormal translation ( J:265010 )

• in mouse embryonic fibroblasts

embryo

embryonic growth retardation ( J:265010 )

decreased embryo size ( J:265010 )

• intermediate

growth/size/body

embryonic growth retardation ( J:265010 )

decreased embryo size ( J:265010 )

• intermediate

decreased body weight ( J:265010 )

♀ • in female but not male mice from weaning to 9 weeks of age

liver/biliary system

small liver ( J:265010 )

• in embryos despite normal liver cell size

homeostasis/metabolism

abnormal translation ( J:265010 )

• in mouse embryonic fibroblasts