Phenotypes associated with this allele

• Allele Symbol: Wdr73^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6294116
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr73^em1(IMPC)J/Wdr73^em1(IMPC)J	C57BL/6NJ-Wdr73^em1(IMPC)J/Mmjax	MGI:6493197
ht2	Wdr73^em1(IMPC)J/Wdr73^+	C57BL/6NJ-Wdr73^em1(IMPC)J/Mmjax	MGI:7317095

Genotype
MGI:6493197

hm1

• Allelic Composition: Wdr73^em1(IMPC)J/Wdr73^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Wdr73^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Wdr73

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Wdr73^em1(IMPC)J/Wdr73^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form irregular outgrowths.

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• homozygous embryos are recovered as blastocysts at E3.5 but not found at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:7317095

ht2

• Allelic Composition: Wdr73^em1(IMPC)J/Wdr73⁺
• Genetic Background: C57BL/6NJ-Wdr73^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Wdr73

homeostasis/metabolism

decreased circulating calcium level ( J:211773 )

IMPC - JAX