Analysis Tools
mortality/aging
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• mice do not survive gestation
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Allele Symbol Allele Name Allele ID |
Sting1em1Jmin endonuclease-mediated mutation 1, Jonathan Miner MGI:6287305 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice do not survive gestation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• spleens show reduced numbers of T cells, which is more severe for CD8+ T cells than for CD4+ T cells, indicating T cell cytopenia
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• spleens show an expansion of Ly6G+ myeloid cells and immature myeloid cells
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• abnormal spleen architecture
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• 3 of 5 mice produce higher levels of IgM but not IgG autoantibodies
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• lungs show organized thrombosis in pulmonary blood vessels
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• 4-6 month old mice exhibit elevated levels of multiple cytokines and chemokines, including TNF, IL-17a, IL-13, G-CSF, MIP-1alpha, MIP-1beta, MCP-1, and IL-10
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• in 4-6 month old mice
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• in 4-6 month old mice
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• in 4-6 month old mice
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• spleens show reduced numbers of T cells, which is more severe for CD8+ T cells than for CD4+ T cells, indicating T cell cytopenia
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• abnormal spleen architecture
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• 3 of 5 mice produce higher levels of IgM but not IgG autoantibodies
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• 4-6 month old mice exhibit elevated levels of multiple cytokines and chemokines, including TNF, IL-17a, IL-13, G-CSF, MIP-1alpha, MIP-1beta, MCP-1, and IL-10
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• in 4-6 month old mice
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• in 4-6 month old mice
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• in 4-6 month old mice
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• lungs show chronic perivascular inflammation with heterogeneous immune cell infiltration
• immune cells consist predominantly of CD19+ B cells and CD11b+ myeloid cells, with smaller numbers of CD4+ and CD8+ T cells
• however, pulmonary fibrosis is not seen
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• skin lesions show mixed immune cell infiltration, ulceration, and scarring
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• ulcerative skin lesions of the extremities are seen in 5 mice and on the head in 1 mouse
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• lungs show chronic perivascular inflammation with heterogeneous immune cell infiltration
• immune cells consist predominantly of CD19+ B cells and CD11b+ myeloid cells, with smaller numbers of CD4+ and CD8+ T cells
• however, pulmonary fibrosis is not seen
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• severe respiratory distress occurs frequently
• severe respiratory distress is sometimes seen during late pregnancy in dams that are unable to survive labor
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| N |
• mice show no evidence of inflamed or abnormal glomeruli
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| STING-associated vasculopathy with onset in infancy | DOID:0111457 |
OMIM:615934 |
J:251372 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the percent and absolute number of CD8+ T cells in spleen is reduced to a similar level as in single Sting1em1Jmin homozygotes
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• spleen shows a similar increase in the number of Ly6G+ and Ly6C+ myeloid cell populations as in single Sting1em1Jmin homozygotes
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• the percent and absolute number of CD8+ T cells in spleen is reduced to a similar level as in single Sting1em1Jmin homozygotes
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• mice exhibit a similar level of perivascular immune cell infiltration as single Sting1em1Jmin homozygotes
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• mice exhibit a similar level of perivascular immune cell infiltration as single Sting1em1Jmin homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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