Analysis Tools
homeostasis/metabolism
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• a modest 20% decrease in forebrain levels of D-serine in newborn mice, with no differences at P7, a slight increase at P21 and no differences at P90
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• mice exhibit an approximate 45% decrease in generation of D-serine from L-serine
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behavior/neurological
| N |
• no differences from controls are seen in anxiety in the elevated plus maze, spontaneous alternations, or special recognition memory in the Y maze
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• mice treated with an NMDA antagonist MK-801 show greater locomotor stimulation and a greater disruption in pre-pulse inhibition at intensities of pre-pulses of 4 dB and 8 dB than controls
• supplementation with D-serine of MK-801 treated mice reduces hyperactivity of mutants more than wild-type mice and increases the reduction of pre-pulse inhibition indicating increased sensitivity to the effects of D-serine
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• mice treated with an NMDA antagonist MK-801 show greater locomotor stimulation than control mice
• supplementation with D-serine of MK-801 treated mice reduces hyperactivity of mutants more than wild-type mice
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nervous system
| N |
• mice show no gross defects in cytoarchitecture and layer of the hippocampus or cerebellum
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• mice treated with MK-801 show a greater disruption in pre-pulse inhibition at intensities of pre-pulses of 4 dB and 8 dB than controls
• supplementation with D-serine of MK-801 treated mice increases the reduction of pre-pulse inhibition
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