About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp3cbm5Btlr
mutation 5, Bruce Beutler
MGI:6286021
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp3cbm5Btlr/Ppp3cbm5Btlr C57BL/6J-Ppp3cbm5Btlr MGI:6286023


Genotype
MGI:6286023
hm1
Allelic
Composition		 Ppp3cbm5Btlr/Ppp3cbm5Btlr
Genetic
Background		 C57BL/6J-Ppp3cbm5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbm5Btlr mutation (0 available); any Ppp3cb mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:272839 )
• increase in the CD4 to CD8 T cell ratio in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:272839 )
• reduced frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system
abnormal T cell morphology ( J:272839 )
• increase in the CD4 to CD8 T cell ratio in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:272839 )
• reduced frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory