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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp3cbm5Btlr
mutation 5, Bruce Beutler
MGI:6286021
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp3cbm5Btlr/Ppp3cbm5Btlr C57BL/6J-Ppp3cbm5Btlr MGI:6286023


Genotype
MGI:6286023
hm1
Allelic
Composition		 Ppp3cbm5Btlr/Ppp3cbm5Btlr
Genetic
Background		 C57BL/6J-Ppp3cbm5Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3cbm5Btlr mutation (0 available); any Ppp3cb mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:272839 )
• increase in the CD4 to CD8 T cell ratio in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:272839 )
• reduced frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system
abnormal T cell morphology ( J:272839 )
• increase in the CD4 to CD8 T cell ratio in the peripheral blood
decreased CD8-positive, alpha-beta T cell number ( J:272839 )
• reduced frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory