Phenotypes associated with this allele

• Allele Symbol: Atm^m5Btlr
• Allele Name: mutation 5, Bruce Beutler
• Allele ID: MGI:6285932
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atm^m5Btlr/Atm^m5Btlr	C57BL/6J-Atm^m5Btlr	MGI:6285934

Genotype
MGI:6285934

hm1

• Allelic Composition: Atm^m5Btlr/Atm^m5Btlr
• Genetic Background: C57BL/6J-Atm^m5Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage phagocytosis ( J:272824 )

• defective phagocytosis of peritoneal exudate cells

abnormal lymphocyte morphology ( J:272824 )

• increased B to T cell ratios in the peripheral blood

increased B-1 B cell number ( J:272824 )

• increased frequencies of peripheral blood B1 cells in the peripheral blood

decreased interleukin-1 beta secretion ( J:272824 )

• reduced secretion of the proinflammatory cytokine interleukin (IL)-1beta in response to priming with lipopolysaccharide (LPS) followed bynigericin treatment (i.e., NLRP3 inflammasome signaling defect)

cellular

impaired macrophage phagocytosis ( J:272824 )

• defective phagocytosis of peritoneal exudate cells

hematopoietic system

impaired macrophage phagocytosis ( J:272824 )

• defective phagocytosis of peritoneal exudate cells

abnormal lymphocyte morphology ( J:272824 )

• increased B to T cell ratios in the peripheral blood

increased B-1 B cell number ( J:272824 )

• increased frequencies of peripheral blood B1 cells in the peripheral blood