About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		PtprcM9Btlr
mutation 9, Bruce Beutler
MGI:6285650
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		PtprcM9Btlr/PtprcM9Btlr C57BL/6J-PtprcM9Btlr MGI:6285652


Genotype
MGI:6285652
hm1
Allelic
Composition		 PtprcM9Btlr/PtprcM9Btlr
Genetic
Background		 C57BL/6J-PtprcM9Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
PtprcM9Btlr mutation (0 available); any Ptprc mutation (212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte morphology ( J:272745 )
• reduced B to T cell ratios in the peripheral blood
abnormal B cell differentiation ( J:272745 )
• reduced B220 expression on peripheral blood B cells
decreased B cell number ( J:272745 )
• reduced frequencies of B cells
decreased NK cell number ( J:272745 )
• reduced frequencies of NK cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of effector memory CD4 T cells in CD4 T cell
abnormal CD8-positive, alpha beta T cell morphology ( J:272745 )
• increased frequencies of CD44+ CD8 T cells
increased CD8-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of central memory CD4 T cells in CD4 T cells

cardiovascular system
decreased systemic arterial systolic blood pressure ( J:272745 )
• reduced systolic blood pressures

hematopoietic system
abnormal lymphocyte morphology ( J:272745 )
• reduced B to T cell ratios in the peripheral blood
abnormal B cell differentiation ( J:272745 )
• reduced B220 expression on peripheral blood B cells
decreased B cell number ( J:272745 )
• reduced frequencies of B cells
decreased NK cell number ( J:272745 )
• reduced frequencies of NK cells
increased effector memory CD4-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of effector memory CD4 T cells in CD4 T cell
abnormal CD8-positive, alpha beta T cell morphology ( J:272745 )
• increased frequencies of CD44+ CD8 T cells
increased CD8-positive, alpha-beta T cell number ( J:272745 )
• increased frequencies of central memory CD4 T cells in CD4 T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory