Phenotypes associated with this allele

• Allele Symbol: Dock2^m11Btlr
• Allele Name: mutation 11, Bruce Beutler
• Allele ID: MGI:6284840
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dock2^m11Btlr/Dock2^m11Btlr	C57BL/6J-Dock2^m11Btlr	MGI:6284842

Genotype
MGI:6284842

hm1

• Allelic Composition: Dock2^m11Btlr/Dock2^m11Btlr
• Genetic Background: C57BL/6J-Dock2^m11Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:272405 )

• reduced B220 expression on peripheral blood B cells

abnormal CD4-positive T cell differentiation ( J:272405 )

• increased CD44 expression on peripheral blood CD4+ T cells

increased B-1 B cell number ( J:272405 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:272405 )

• reduced frequencies of B cells in the peripheral blood

• reduced peripheral blood B to T cell ratios

decreased NK cell number ( J:272405 )

• reduced frequencies of NK cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272405 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272405 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:272405 )

• increased CD44 expression on peripheral blood CD8+ T cells

hematopoietic system

abnormal B cell differentiation ( J:272405 )

• reduced B220 expression on peripheral blood B cells

abnormal CD4-positive T cell differentiation ( J:272405 )

• increased CD44 expression on peripheral blood CD4+ T cells

increased B-1 B cell number ( J:272405 )

• increased frequencies of B1 cells in the peripheral blood

decreased B cell number ( J:272405 )

• reduced frequencies of B cells in the peripheral blood

• reduced peripheral blood B to T cell ratios

decreased NK cell number ( J:272405 )

• reduced frequencies of NK cells in the peripheral blood

increased central memory CD4-positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of central memory CD4 T cells in CD4 T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272405 )

• reduced frequencies of CD4+ T cells and CD4+ T cells in CD3+ T cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272405 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of CD8+ T cells and CD8+ T cells in CD3+ T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272405 )

• increased frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:272405 )

• increased CD44 expression on peripheral blood CD8+ T cells