All Phenotypes Rag1<m4Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rag1^m4Btlr
mutation 4, Bruce Beutler
MGI:6283875

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rag1^m4Btlr/Rag1^m4Btlr	C57BL/6J-Rag1^m4Btlr	MGI:6283877

Allelic Composition	Rag1^m4Btlr/Rag1^m4Btlr
Genetic Background	C57BL/6J-Rag1^m4Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^m4Btlr mutation (0 available); any Rag1 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:272094 )

• CD44 expression was increased on peripheral blood T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272094 )

• CD44 expression was increased on peripheral blood CD8+ T cells

decreased B cell number ( J:272094 )

• reduced frequencies of B cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272094 )

• reduced frequencies of naive CD8 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272094 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272094 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272094 )

• increased frequencies of central memory CD8 T cells in the peripheral blood

hematopoietic system

abnormal T cell differentiation ( J:272094 )

• CD44 expression was increased on peripheral blood T cells

abnormal CD8-positive, alpha-beta T cell differentiation ( J:272094 )

• CD44 expression was increased on peripheral blood CD8+ T cells

decreased B cell number ( J:272094 )

• reduced frequencies of B cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272094 )

• reduced frequencies of naive CD8 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272094 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272094 )

• increased frequencies of CD44+ CD8 T cells in the peripheral blood

increased central memory CD8 positive, alpha-beta T cell number ( J:272094 )

• increased frequencies of central memory CD8 T cells in the peripheral blood

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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