Phenotypes associated with this allele

• Allele Symbol: Nckap1l^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:6283866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nckap1l^m1Btlr/Nckap1l^m1Btlr	C57BL/6J-Nckap1l^m1Btlr	MGI:6283868

Genotype
MGI:6283868

hm1

• Allelic Composition: Nckap1l^m1Btlr/Nckap1l^m1Btlr
• Genetic Background: C57BL/6J-Nckap1l^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:272079 )

• reduced peripheral blood B to T cell ratios

decreased NK cell number ( J:272079 )

• reduced frequencies of NK cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272079 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased alpha-beta T cell number ( J:272079 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272079 )

• reduced frequencies of NK cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:272079 )

• reduced frequencies of CD8+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:272079 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272079 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272079 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272079 )

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:272079 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood

growth/size/body

decreased body weight ( J:272079 )

• reduced body weights compared to wild-type littermates

hematopoietic system

decreased B cell number ( J:272079 )

• reduced peripheral blood B to T cell ratios

decreased NK cell number ( J:272079 )

• reduced frequencies of NK cells in the peripheral blood

decreased CD8-positive, naive alpha-beta T cell number ( J:272079 )

• reduced frequencies of naive CD8 T cells in CD8 T cells in the peripheral blood

decreased alpha-beta T cell number ( J:272079 )

• reduced frequencies of T cells in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:272079 )

• reduced frequencies of NK cells in the peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:272079 )

• reduced frequencies of CD8+ T cells in the peripheral blood

decreased central memory CD8 positive, alpha-beta T cell number ( J:272079 )

• reduced frequencies of central memory CD8 T cells in CD8 T cells in the peripheral blood

increased alpha-beta T cell number ( J:272079 )

• increased frequencies of CD44+ T cells in the peripheral blood

increased effector memory CD4-positive, alpha-beta T cell number ( J:272079 )

• increased frequencies of effector memory CD4 T cells in CD4 T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:272079 )

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:272079 )

• increased frequencies of effector memory CD8 T cells in CD8 T cells in the peripheral blood