Phenotypes associated with this allele

• Allele Symbol: Tcf12^m4Btlr
• Allele Name: mutation 4, Bruce Beutler
• Allele ID: MGI:6283526
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf12^m4Btlr/Tcf12^m4Btlr	C57BL/6J-Tcf12^m4Btlr	MGI:6283530

Genotype
MGI:6283530

hm1

• Allelic Composition: Tcf12^m4Btlr/Tcf12^m4Btlr
• Genetic Background: C57BL/6J-Tcf12^m4Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell morphology ( J:271972 )

• reduced B to T cell ratios in the peripheral blood

abnormal T cell morphology ( J:271972 )

• reduced CD4 to CD8 T cell ratios in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:271972 )

• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:271972 )

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood

hematopoietic system

abnormal B cell morphology ( J:271972 )

• reduced B to T cell ratios in the peripheral blood

abnormal T cell morphology ( J:271972 )

• reduced CD4 to CD8 T cell ratios in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:271972 )

• reduced frequencies of CD4+ T cells in CD3+ T cells in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:271972 )

• increased frequencies of CD8+ T cells in CD3+ T cells in the peripheral blood