Phenotypes associated with this allele

• Allele Symbol: Prmt7^tm1.1Rchd
• Allele Name: targeted mutation 1.1, Stephane Richard
• Allele ID: MGI:6281577
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prmt7^tm1.1Rchd/Prmt7^tm1.1Rchd Pax7^tm1(cre/ERT2)Gaka/Pax7^+	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NCrl	MGI:6314346

Genotype
MGI:6314346

cn1

• Allelic Composition: Prmt7^tm1.1Rchd/Prmt7^tm1.1Rchd; Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle physiology ( J:271361 )

• satellite cells isolated from 8 month tamoxifen-treated mice exhibit premature senescence unlike control cells

impaired skeletal muscle regeneration ( J:271361 )

• tamoxifen-treated mice subjected to cardiotoxin-induced muscle injury exhibit smaller and poorly organized regenerating myofibers compared with control mice

cellular

early cellular replicative senescence ( J:271361 )

• satellite cells or cardiotoxin-injured tibialis anterior muscles isolated from 8 month tamoxifen-treated mice exhibit premature senescence unlike control cells

homeostasis/metabolism

abnormal response to injury ( J:271361 )

• cardiotoxin-injured tibialis anterior muscles isolated from 8 month tamoxifen-treated mice exhibit premature senescence unlike control cells