Phenotypes associated with this allele

• Allele Symbol: Abhd15^tm1Jgbs
• Allele Name: targeted mutation 1, Juliane G Bogner-Strauss
• Allele ID: MGI:6281435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abhd15^tm1Jgbs/Abhd15^tm1Jgbs Tg(Adipoq-cre)1Evdr/0	B6.Cg-Tg(Adipoq-cre)1Evdr Abhd15^tm1Jgbs	MGI:8240380

Genotype
MGI:8240380

cn1

• Allelic Composition: Abhd15^tm1Jgbs/Abhd15^tm1Jgbs; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: B6.Cg-Tg(Adipoq-cre)1Evdr Abhd15^tm1Jgbs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:270787 )

N • at 20-22 weeks of age, mice fed a high-glucose diet (HGD) show no differences in body weight or body mass composition relative to age- and diet-matched wild-type controls

decreased body fat mass ( J:270787 )

• at 20-22 weeks of age, chow-fed mice show reduced fat mass in the overnight fasted and fed states

increased lean body mass ( J:270787 )

• at 20-22 weeks of age, chow-fed mice show increased lean body mass in the overnight fasted and fed states

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:270787 )

N • at 20-22 weeks of age, chow-fed mice show normal energy expenditure (EE) over 3 days (EE includes overnight fasting and 6 h refeeding) and normal plasma insulin and adiponectin levels after overnight fasting and 1 h refeeding

N • mice fed a high-glucose diet (HGD) show no changes in EE or plasma insulin levels

decreased respiratory quotient ( J:270787 )

• at 30 weeks of age, HGD-fed mice show a significantly lower respiratory exchange ratio (RER = VCO2/VO2) during overnight fasting and in the 6 h-refed state, suggesting preferential oxidation of lipids during the dark phase and in the refed state

impaired glucose tolerance ( J:270787 )

• HGD-fed mice show markedly impaired glucose tolerance

insulin resistance ( J:270787 )

• HGD-fed mice show markedly reduced insulin sensitivity

decreased circulating adiponectin level ( J:270787 )

• HGD-fed mice show significantly lower plasma adiponectin concentrations

abnormal protein level ( J:270787 )

• HGD-fed mice show significantly reduced PDE3B (phosphodiesterase 3B, cGMP-inhibited) protein levels in epididymal WAT (eWAT)

abnormal lipid metabolism ( J:270787 )

• HGD-fed mice show significantly reduced mRNA expression of lipid metabolism genes (Dgat1, Acsl1, Acot3, Acot4, Hmgcs1, Abcg1 and Ldlr) and of Pde3b (phosphodiesterase 3B, cGMP-inhibited) in eWAT in the 1 h-refed state

enhanced lipolysis ( J:270787 )

• on a standard chow diet, 20-week-old mice fasted overnight and then i.p. injected with 0.3 U/kg insulin show significantly higher plasma fatty acid (FA) levels than similarly treated wild-type controls at 15-, 30- and 60- min postinjection

• similarly, on a chow diet, 20-week-old mice fasted overnight and then i.g. gavaged with 2.5 g/kg glucose to stimulate insulin secretion show significantly higher plasma FA levels than similarly treated wild-type controls at 15-min, but not at 30-min or 60-min, post gavage

adipose tissue

decreased body fat mass ( J:270787 )

• at 20-22 weeks of age, chow-fed mice show reduced fat mass in the overnight fasted and fed states

behavior/neurological

behavior/neurological phenotype ( J:270787 )

N • at 20-22 weeks of age, chow-fed mice show normal food intake, as measured over 3 days